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Men presenting with UTI symptoms warrant careful evaluation, as UTIs in men are generally considered complicated infections and may indicate underlying urological abnormalities such as prostatic hypertrophy or urinary retention requiring further investigation

Dysbiosis may increase luminal histamine or and inhibit the action of dao enzymes, leading to increased histamine levels

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Preclinical studies from our group and others have demonstrated that dual inhibition of IDO1 and TDO2, especially when combined with anti-PD1 therapy, can significantly improve survival in mouse models of lung cancer (47, 48)